Drug reference
memantine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Alzheimer's Drugs)
Mechanism of action
Low- to moderate-affinity uncompetitive N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonist that binds preferentially to NMDAR-operated cation channels, blocking receptor only under conditions of excessive stimulation, with no effect on normal neurotransmission
Common side effects
- Constipation
- Dizziness
- Headache
- Back pain
- Confusion
- Cough
- Hypertension
Known interactions (1)
- dextromethorphan + memantine Moderate
Related conditions
Frequently asked questions
What drug class is memantine?
memantine belongs to: Central Nervous System.
How does memantine work?
Low- to moderate-affinity uncompetitive N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonist that binds preferentially to NMDAR-operated cation channels, blocking receptor only under conditions of excessive stimulation, with no effect on normal neurotransmission
What are the common side effects of memantine?
Constipation, Dizziness, Headache, Back pain, Confusion, Cough, Hypertension
Which drugs interact with memantine?
dextromethorphan
Full monographs, dosing and an interaction checker in the MediHelp app
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