Drug interactions
Dofetilide + Memantine
Severity: Moderate
Dofetilide and Memantine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are cationic and secreted by renal tubules, so competition could raise concentrations of either. Dofetilide has a narrow therapeutic index with risk of torsades de pointes, making any rise important.
What this interaction means in plain words
Dofetilide and Memantine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dofetilide belongs to Cardiovascular; Memantine belongs to Central Nervous System.
Why it happens
Competition for renal tubular cationic secretion (OCT2).
What to do
Monitor QTc and renal function, and watch for memantine adverse effects such as dizziness and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Memantine + Procainamide Moderate
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Memantine?
MediHelp rates the interaction as moderate. Dofetilide and Memantine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are cationic and secreted by renal tubules, so competition could raise concentrations of either. Dofetilide has a narrow therapeutic index with risk of torsades de pointes, making any rise important.
How serious is the interaction between Dofetilide and Memantine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor QTc and renal function, and watch for memantine adverse effects such as dizziness and confusion.
What other medicines interact with Memantine?
MediHelp also lists interactions of Memantine with, for example, Ketamine, Acetazolamide, Aluminum hydroxide. The full list is on the Memantine page.
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