Drug interactions
Levoketoconazole + Nilotinib
Severity: Contraindicated
Levoketoconazole and Nilotinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and raises nilotinib exposure. Both drugs also prolong the QT interval, so the risk of torsades de pointes is substantially increased.
What this interaction means in plain words
Levoketoconazole and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition raises nilotinib concentrations, with additive QT prolongation.
What to do
Avoid the combination. If an alternative to either drug is impossible, reduce the nilotinib dose per labeling and monitor ECG closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Nilotinib?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 inhibitor and raises nilotinib exposure. Both drugs also prolong the QT interval, so the risk of torsades de pointes is substantially increased.
How serious is the interaction between Levoketoconazole and Nilotinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If an alternative to either drug is impossible, reduce the nilotinib dose per labeling and monitor ECG closely.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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