Drug interactions
Ibutilide + Nilotinib
Severity: Contraindicated
Ibutilide and Nilotinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide strongly prolongs repolarization and has a high torsades risk. Adding nilotinib, which also prolongs QT, further increases the likelihood of life-threatening ventricular arrhythmia.
What this interaction means in plain words
Ibutilide and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Additive QT prolongation via potassium channel blockade.
What to do
Do not use together. Consider another rhythm-control approach such as electrical cardioversion.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Nilotinib?
MediHelp rates the interaction as contraindicated. Ibutilide and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide strongly prolongs repolarization and has a high torsades risk. Adding nilotinib, which also prolongs QT, further increases the likelihood of life-threatening ventricular arrhythmia.
How serious is the interaction between Ibutilide and Nilotinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Consider another rhythm-control approach such as electrical cardioversion.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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