Drug interactions
Mefloquine + Nilotinib
Severity: Contraindicated
Mefloquine and Nilotinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib carries a boxed warning for QT prolongation and sudden death, and mefloquine can further prolong the QT interval. The combination substantially increases the risk of torsades de pointes.
What this interaction means in plain words
Mefloquine and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mefloquine belongs to Anti Parasitic; Nilotinib belongs to Oncology.
Why it happens
Additive QT prolongation; nilotinib is also a CYP3A4 substrate and inhibitor that may alter mefloquine exposure.
What to do
Avoid the combination and use an antimalarial without QT effects. If it cannot be avoided, monitor the ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Pimozide Contraindicated
- Mefloquine + Quinidine Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Mefloquine with Nilotinib?
MediHelp rates the interaction as contraindicated. Mefloquine and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nilotinib carries a boxed warning for QT prolongation and sudden death, and mefloquine can further prolong the QT interval. The combination substantially increases the risk of torsades de pointes.
How serious is the interaction between Mefloquine and Nilotinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antimalarial without QT effects. If it cannot be avoided, monitor the ECG and electrolytes closely.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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