Drug reference
sofosbuvir
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Anti Virals (Hepatits Viruses)
Mechanism of action
Nucleotide prodrug that undergoes metabolism to the active uridine analog triphosphate, an inhibitor of HCV NS5B RNA-dependent polymerase; its inhibition in turn suppresses viral replication
Common side effects
- Pruritus
- Insomnia
- Headache
- Fatigue
- Nausea
- Diarrhea
Contraindications
- Combination with ribavirin: Hypersensitivity Pregnancy or planning pregnancy, including men whose female partners are pregnant/planning to get pregnant CrCl <50 mL/min Pancreatitis Hemoglobinopathies (eg, thalassemia major, sickle cell anemia) Coadministration with didanosine Autoimmune h…
- Combination with peg-interferon alfa Autoimmune hepatitis, decompensated liver disease (Child-Pugh class B, C) Use in neonates, infants (contains benzyl alcohol)
Known interactions (1)
- amiodarone + sofosbuvir Major
Related conditions
Frequently asked questions
What drug class is sofosbuvir?
sofosbuvir belongs to: Anti Virals.
How does sofosbuvir work?
Nucleotide prodrug that undergoes metabolism to the active uridine analog triphosphate, an inhibitor of HCV NS5B RNA-dependent polymerase; its inhibition in turn suppresses viral replication
What are the common side effects of sofosbuvir?
Pruritus, Insomnia, Headache, Fatigue, Nausea, Diarrhea
Which drugs interact with sofosbuvir?
amiodarone
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