Drug interactions
Oxcarbazepine + Sofosbuvir
Severity: Major
Oxcarbazepine and Sofosbuvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is an inducer that may reduce sofosbuvir exposure and thereby compromise antiviral efficacy. Treatment failure of hepatitis C therapy is the concern.
What this interaction means in plain words
Oxcarbazepine and Sofosbuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxcarbazepine belongs to Central Nervous System; Sofosbuvir belongs to Anti Virals.
Why it happens
Induction of intestinal P-glycoprotein by oxcarbazepine lowers sofosbuvir absorption.
What to do
Avoid coadministration as labeling advises. Consider switching to an anticonvulsant without inducing effects before starting sofosbuvir.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sofosbuvir
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Sofosbuvir?
MediHelp rates the interaction as major. Oxcarbazepine and Sofosbuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine is an inducer that may reduce sofosbuvir exposure and thereby compromise antiviral efficacy. Treatment failure of hepatitis C therapy is the concern.
How serious is the interaction between Oxcarbazepine and Sofosbuvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration as labeling advises. Consider switching to an anticonvulsant without inducing effects before starting sofosbuvir.
What other medicines interact with Sofosbuvir?
MediHelp also lists interactions of Sofosbuvir with, for example, Amiodarone, Apalutamide, Carbamazepine. The full list is on the Sofosbuvir page.
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