Drug interactions
amiodarone + sofosbuvir
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Severe bradycardia (± syncope) reported with DAAs.
Mechanism of action
Unknown; possible conduction effects.
Clinical management
Avoid; if unavoidable, inpatient monitoring recommended.
Drug reference
References
Frequently asked questions
Can I take amiodarone with sofosbuvir?
The interaction is rated: Major. Severe bradycardia (± syncope) reported with DAAs.
How serious is the interaction between amiodarone and sofosbuvir?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between amiodarone and sofosbuvir managed?
Avoid; if unavoidable, inpatient monitoring recommended.
Why do amiodarone and sofosbuvir interact?
Unknown; possible conduction effects.
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