Drug interactions
Apalutamide + Sofosbuvir
Severity: Major
Apalutamide and Sofosbuvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an inducer of P-glycoprotein and other transporters and may lower sofosbuvir exposure. Sofosbuvir labeling advises against use with P-gp inducers because of the risk of reduced antiviral efficacy and treatment failure.
What this interaction means in plain words
Apalutamide and Sofosbuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Sofosbuvir belongs to Anti Virals.
Why it happens
Induction of intestinal P-glycoprotein and BCRP lowers absorption of sofosbuvir.
What to do
Avoid coadministration. Choose an alternative therapy or defer hepatitis C treatment until apalutamide is no longer needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sofosbuvir
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Sofosbuvir?
MediHelp rates the interaction as major. Apalutamide and Sofosbuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is an inducer of P-glycoprotein and other transporters and may lower sofosbuvir exposure. Sofosbuvir labeling advises against use with P-gp inducers because of the risk of reduced antiviral efficacy and treatment failure.
How serious is the interaction between Apalutamide and Sofosbuvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Choose an alternative therapy or defer hepatitis C treatment until apalutamide is no longer needed.
What other medicines interact with Sofosbuvir?
MediHelp also lists interactions of Sofosbuvir with, for example, Amiodarone, Carbamazepine, Fosphenytoin. The full list is on the Sofosbuvir page.
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