Drug reference
ergotamine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Migraine Drugs)
Mechanism of action
Stimulates alpha receptors to vasoconstrict vessels with low vascular tone; vasodilates hypertonic vessels; at higher doses competes for alpha receptor to block it
Common side effects
- Angina
- Abnormal heart valve findings
- Arrhythmia
- Vascular spasm
- Vasoconstriction
Known interactions (39)
- almotriptan + ergotamine Contraindicated
- clarithromycin + ergotamine Contraindicated
- eletriptan + ergotamine Contraindicated
- ergotamine + frovatriptan Contraindicated
- ergotamine + itraconazole Contraindicated
- ergotamine + ketoconazole Contraindicated
- ergotamine + mifepristone Contraindicated
- ergotamine + naratriptan Contraindicated
- ergotamine + ritonavir Contraindicated
- ergotamine + rizatriptan Contraindicated
- ergotamine + sumatriptan Contraindicated
- ergotamine + voriconazole Contraindicated
- ergotamine + zolmitriptan Contraindicated
- adrenaline-articaine + ergotamine Major
- aprepitant + ergotamine Major
- dasatinib + ergotamine Major
- dextroamphetamine + ergotamine Major
- dobutamine + ergotamine Major
- dopamine + ergotamine Major
- dronedarone + ergotamine Major
- efavirenz + ergotamine Major
- epinephrine + ergotamine Major
- ergotamine + fluconazole Major
- ergotamine + lapatinib Major
- ergotamine + lisdexamfetamine Major
- ergotamine + methamphetamine Major
- ergotamine + methylphenidate Major
- ergotamine + miconazole Major
- ergotamine + midodrine Major
- ergotamine + nilotinib Major
- ergotamine + phenylephrine Major
- ergotamine + pseudoephedrine Major
- ergotamine + verapamil Major
- ergotamine + xylometazoline Major
- ergotamine + fluvoxamine Moderate
- ergotamine + nevirapine Moderate
- ergotamine + nitroglycerin Moderate
- ergotamine + phenytoin Moderate
- ergotamine + griseofulvin Minor
Related conditions
Frequently asked questions
What drug class is ergotamine?
ergotamine belongs to: Central Nervous System.
How does ergotamine work?
Stimulates alpha receptors to vasoconstrict vessels with low vascular tone; vasodilates hypertonic vessels; at higher doses competes for alpha receptor to block it
What are the common side effects of ergotamine?
Angina, Abnormal heart valve findings, Arrhythmia, Vascular spasm, Vasoconstriction
Which drugs interact with ergotamine?
almotriptan, clarithromycin, eletriptan, frovatriptan, itraconazole, ketoconazole, mifepristone, naratriptan, ritonavir, rizatriptan, sumatriptan, voriconazole, zolmitriptan, adrenaline-articaine, aprepitant
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