Drug interactions
Linezolid + Sumatriptan
Severity: Major
Linezolid and Sumatriptan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sumatriptan is metabolized by MAO-A, so linezolid can raise its exposure, and both agents also contribute to serotonergic activity. The result may be serotonin syndrome and exaggerated triptan effects.
What this interaction means in plain words
Linezolid and Sumatriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Sumatriptan belongs to Central Nervous System.
Why it happens
Inhibition of MAO-A metabolism of sumatriptan plus additive serotonergic effects.
What to do
Avoid combined use; sumatriptan is contraindicated within 2 weeks of MAOIs. Use non-serotonergic migraine therapy during linezolid and monitor for serotonin toxicity if exposure occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Linezolid with Sumatriptan?
MediHelp rates the interaction as major. Linezolid and Sumatriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sumatriptan is metabolized by MAO-A, so linezolid can raise its exposure, and both agents also contribute to serotonergic activity. The result may be serotonin syndrome and exaggerated triptan effects.
How serious is the interaction between Linezolid and Sumatriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use; sumatriptan is contraindicated within 2 weeks of MAOIs. Use non-serotonergic migraine therapy during linezolid and monitor for serotonin toxicity if exposure occurs.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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