Drug interactions
Acalabrutinib + Hydroxycarbamide
Severity: Moderate
Acalabrutinib and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause myelosuppression, including neutropenia, anemia and thrombocytopenia. Combined use may increase the risk and severity of cytopenias and infection.
What this interaction means in plain words
Acalabrutinib and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acalabrutinib belongs to Oncology; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive bone marrow suppression from hydroxyurea and acalabrutinib.
What to do
Monitor complete blood counts regularly and reduce or hold doses of either drug for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Other interactions of Acalabrutinib
Frequently asked questions
Can I take Acalabrutinib with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Acalabrutinib and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause myelosuppression, including neutropenia, anemia and thrombocytopenia. Combined use may increase the risk and severity of cytopenias and infection.
How serious is the interaction between Acalabrutinib and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and reduce or hold doses of either drug for significant cytopenias.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Adenovirus types 4 and 7 live. The full list is on the Hydroxycarbamide page.
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