Drug interactions
Alefacept + Hydroxycarbamide
Severity: Moderate
Alefacept and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alefacept reduces CD4+ T lymphocytes, and hydroxyurea is myelosuppressive, so the combination may deepen immunosuppression and raise infection risk. Alefacept has been withdrawn from the market in most regions.
What this interaction means in plain words
Alefacept and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression through T-cell depletion by alefacept and myelosuppression by hydroxyurea.
What to do
Monitor CD4+ counts, blood counts and signs of infection, and withhold alefacept if counts fall markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Alefacept with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Alefacept and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alefacept reduces CD4+ T lymphocytes, and hydroxyurea is myelosuppressive, so the combination may deepen immunosuppression and raise infection risk. Alefacept has been withdrawn from the market in most regions.
How serious is the interaction between Alefacept and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor CD4+ counts, blood counts and signs of infection, and withhold alefacept if counts fall markedly.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Adenovirus types 4 and 7 live. The full list is on the Hydroxycarbamide page.
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