Drug interactions
Alemtuzumab + Hydroxycarbamide
Severity: Moderate
Alemtuzumab and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress bone marrow and lymphocyte function. Used together they can deepen cytopenias and prolong immune suppression, raising the risk of serious infection and bleeding.
What this interaction means in plain words
Alemtuzumab and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alemtuzumab belongs to Miscellaneous; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive myelosuppressive and immunosuppressive pharmacodynamic effects.
What to do
Monitor complete blood counts frequently and watch for infection. Reduce the hydroxyurea dose or interrupt therapy if neutropenia or thrombocytopenia becomes significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Other interactions of Alemtuzumab
- Alemtuzumab + Fingolimod Major
- Alemtuzumab + Ifosfamide Major
- Alemtuzumab + Lomustine Major
- Alemtuzumab + Ozanimod Major
- Alemtuzumab + Siponimod Major
- Alemtuzumab + Upadacitinib Major
Frequently asked questions
Can I take Alemtuzumab with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Alemtuzumab and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress bone marrow and lymphocyte function. Used together they can deepen cytopenias and prolong immune suppression, raising the risk of serious infection and bleeding.
How serious is the interaction between Alemtuzumab and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and watch for infection. Reduce the hydroxyurea dose or interrupt therapy if neutropenia or thrombocytopenia becomes significant.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Adenovirus types 4 and 7 live. The full list is on the Hydroxycarbamide page.
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