Drug interactions
Alogliptin-metformin + Linezolid
Severity: Moderate
Alogliptin-metformin and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid has been associated with hypoglycemia in diabetic patients taking insulin or oral antidiabetic drugs. It can also cause lactic acidosis on its own, which is a concern alongside metformin.
What this interaction means in plain words
Alogliptin-metformin and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-metformin belongs to Endocrine; Linezolid belongs to Anti Bacterial.
Why it happens
Linezolid inhibits mitochondrial protein synthesis, which can cause lactic acidosis, and it may enhance glucose lowering by a mechanism that is not fully established.
What to do
Monitor blood glucose during linezolid therapy and watch for symptoms of lactic acidosis such as nausea, malaise, or rapid breathing. Check lactate and stop metformin if acidosis is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alogliptin-metformin
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Alogliptin-metformin with Linezolid?
MediHelp rates the interaction as moderate. Alogliptin-metformin and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid has been associated with hypoglycemia in diabetic patients taking insulin or oral antidiabetic drugs. It can also cause lactic acidosis on its own, which is a concern alongside metformin.
How serious is the interaction between Alogliptin-metformin and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during linezolid therapy and watch for symptoms of lactic acidosis such as nausea, malaise, or rapid breathing. Check lactate and stop metformin if acidosis is suspected.
What other medicines interact with Alogliptin-metformin?
MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.
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