Drug interactions
Alprazolam + Amitriptyline
Severity: Moderate
Alprazolam and Amitriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use increases sedation, psychomotor impairment and risk of falls, and amitriptyline's anticholinergic effects may worsen confusion in older patients.
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
Drug class
- Alprazolam
- Central Nervous System
- Amitriptyline
- Central Nervous System
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