Drug interactions
Alprazolam + Ethinyl estradiol-drospirenone
Severity: Minor
Alprazolam and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives can reduce the oxidative clearance of alprazolam and raise its levels. This may increase sedation and psychomotor impairment.
What this interaction means in plain words
Alprazolam and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated alprazolam metabolism by ethinyl estradiol.
What to do
Monitor for excessive sedation and reduce the alprazolam dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Alprazolam and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral contraceptives can reduce the oxidative clearance of alprazolam and raise its levels. This may increase sedation and psychomotor impairment.
How serious is the interaction between Alprazolam and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the alprazolam dose if needed.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Aminocaproic acid. The full list is on the Ethinyl estradiol-drospirenone page.
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