Drug interactions
Alprazolam + Flibanserin
Severity: Moderate
Alprazolam and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and combined use increases the risk of somnolence, dizziness and impaired psychomotor performance. Flibanserin labeling warns of additive CNS depression with other CNS depressants.
What this interaction means in plain words
Alprazolam and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Counsel patients about sedation and avoid driving until alertness is known; consider dose reduction or avoiding the combination if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Flibanserin?
MediHelp rates the interaction as moderate. Alprazolam and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and combined use increases the risk of somnolence, dizziness and impaired psychomotor performance. Flibanserin labeling warns of additive CNS depression with other CNS depressants.
How serious is the interaction between Alprazolam and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about sedation and avoid driving until alertness is known; consider dose reduction or avoiding the combination if excessive drowsiness occurs.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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