Drug interactions
Alprazolam + Lapatinib
Severity: Moderate
Alprazolam and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a weak-to-moderate CYP3A4 inhibitor and may raise alprazolam exposure, increasing sedation and psychomotor impairment. The effect is likely modest but clinically relevant in sensitive patients.
What this interaction means in plain words
Alprazolam and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated alprazolam metabolism by lapatinib.
What to do
Monitor for excessive sedation and consider a lower alprazolam dose. Counsel patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Other interactions of Lapatinib
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Alprazolam with Lapatinib?
MediHelp rates the interaction as moderate. Alprazolam and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib is a weak-to-moderate CYP3A4 inhibitor and may raise alprazolam exposure, increasing sedation and psychomotor impairment. The effect is likely modest but clinically relevant in sensitive patients.
How serious is the interaction between Alprazolam and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider a lower alprazolam dose. Counsel patients about driving and alcohol.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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