Drug interactions
Alprazolam + Nilotinib
Severity: Moderate
Alprazolam and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a moderate CYP3A4 inhibitor and can raise alprazolam concentrations, increasing sedation and psychomotor impairment. Nilotinib also prolongs the QT interval, but that is not affected by alprazolam.
What this interaction means in plain words
Alprazolam and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4-mediated metabolism of alprazolam, reducing its clearance.
What to do
Monitor for excessive sedation and consider a lower alprazolam starting dose during nilotinib therapy. Reassess the dose if nilotinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Nilotinib?
MediHelp rates the interaction as moderate. Alprazolam and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is a moderate CYP3A4 inhibitor and can raise alprazolam concentrations, increasing sedation and psychomotor impairment. Nilotinib also prolongs the QT interval, but that is not affected by alprazolam.
How serious is the interaction between Alprazolam and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider a lower alprazolam starting dose during nilotinib therapy. Reassess the dose if nilotinib is stopped.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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