Drug interactions
Alprazolam + Omeprazole
Severity: Minor
Alprazolam and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole has no meaningful effect on alprazolam exposure. Alprazolam is cleared mainly by CYP3A4, which omeprazole does not significantly inhibit.
What this interaction means in plain words
Alprazolam and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; interaction is largely theoretical.
What to do
No adjustment needed; monitor for sedation as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Omeprazole?
MediHelp rates the interaction as minor. Alprazolam and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omeprazole has no meaningful effect on alprazolam exposure. Alprazolam is cleared mainly by CYP3A4, which omeprazole does not significantly inhibit.
How serious is the interaction between Alprazolam and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor for sedation as usual.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Acalabrutinib. The full list is on the Omeprazole page.
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