Drug interactions
Alprazolam + Papaverine
Severity: Minor
Alprazolam and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine may cause some drowsiness and dizziness, which could add modestly to alprazolam sedation. The documented evidence for a meaningful interaction is limited.
What this interaction means in plain words
Alprazolam and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Papaverine belongs to Cardiovascular.
Why it happens
Possible additive CNS depressant effects; the mechanism is not well established.
What to do
Counsel patients about additive drowsiness and caution with driving. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Papaverine?
MediHelp rates the interaction as minor. Alprazolam and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine may cause some drowsiness and dizziness, which could add modestly to alprazolam sedation. The documented evidence for a meaningful interaction is limited.
How serious is the interaction between Alprazolam and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and caution with driving. No dose change is usually needed.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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