Drug interactions
Alprazolam + Perampanel
Severity: Moderate
Alprazolam and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel causes dizziness, somnolence and gait disturbance, and combining it with a benzodiazepine can intensify these effects and impair cognition and coordination. Perampanel can also cause psychiatric effects such as irritability, which warrant monitoring.
What this interaction means in plain words
Alprazolam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depression, with perampanel AMPA antagonism plus GABA-A potentiation by alprazolam.
What to do
Counsel on driving and fall risk, and monitor for sedation and mood or behavior changes. Titrate perampanel slowly and lower doses if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Perampanel?
MediHelp rates the interaction as moderate. Alprazolam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel causes dizziness, somnolence and gait disturbance, and combining it with a benzodiazepine can intensify these effects and impair cognition and coordination. Perampanel can also cause psychiatric effects such as irritability, which warrant monitoring.
How serious is the interaction between Alprazolam and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on driving and fall risk, and monitor for sedation and mood or behavior changes. Titrate perampanel slowly and lower doses if sedation is excessive.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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