Drug interactions
Alprazolam + Perphenazine
Severity: Moderate
Alprazolam and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so together they can cause greater sedation, hypotension and impaired psychomotor performance. Older patients are especially vulnerable to falls and confusion.
What this interaction means in plain words
Alprazolam and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and dopaminergic, histaminic and adrenergic blockade.
What to do
Use the lowest effective doses and monitor sedation and blood pressure. Advise avoiding alcohol and caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Other interactions of Perphenazine
Frequently asked questions
Can I take Alprazolam with Perphenazine?
MediHelp rates the interaction as moderate. Alprazolam and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so together they can cause greater sedation, hypotension and impaired psychomotor performance. Older patients are especially vulnerable to falls and confusion.
How serious is the interaction between Alprazolam and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure. Advise avoiding alcohol and caution with driving.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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