Drug reference
perphenazine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Anti Psychotic)
Mechanism of action
Antipsychotic that blocks postsynaptic mesolimbic dopaminergic receptors in the brain; it has moderate anticholinergic effects, weak to moderate sedative effects, strong extrapyramidal effects, and strong antiemetic activity
Common side effects
- Confusion
- Akathisia
- Dystonia
- Decreased gag reflex
- Muscle stiffness
Known interactions (5)
- amisulpride + perphenazine Major
- cabergoline + perphenazine Major
- dopamine + perphenazine Moderate
- indapamide + perphenazine Moderate
- isocarboxazid + perphenazine Moderate
Related conditions
Frequently asked questions
What drug class is perphenazine?
perphenazine belongs to: Central Nervous System.
How does perphenazine work?
Antipsychotic that blocks postsynaptic mesolimbic dopaminergic receptors in the brain; it has moderate anticholinergic effects, weak to moderate sedative effects, strong extrapyramidal effects, and strong antiemetic activity
What are the common side effects of perphenazine?
Confusion, Akathisia, Dystonia, Decreased gag reflex, Muscle stiffness
Which drugs interact with perphenazine?
amisulpride, cabergoline, dopamine, indapamide, isocarboxazid
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