Drug interactions
Alprazolam + Prochlorperazine
Severity: Moderate
Alprazolam and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a phenothiazine with a benzodiazepine increases sedation, psychomotor impairment and the risk of hypotension and falls. Respiratory depression is uncommon but possible, especially in older or frail patients.
What this interaction means in plain words
Alprazolam and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depression through different receptor mechanisms (dopamine, histamine and GABA-A).
What to do
Use the lowest effective doses and monitor sedation and blood pressure; warn patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Prochlorperazine?
MediHelp rates the interaction as moderate. Alprazolam and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a phenothiazine with a benzodiazepine increases sedation, psychomotor impairment and the risk of hypotension and falls. Respiratory depression is uncommon but possible, especially in older or frail patients.
How serious is the interaction between Alprazolam and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure; warn patients about driving and alcohol.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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