Drug reference
prochlorperazine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Anti Psychotic)
Mechanism of action
Antiemetic: Antidopaminergic effect, blocking dopamine receptors in the brain, blocking vagus nerve in GI tract. Antipsychotic: Blocking mesolimbic dopamine receptors, and blocking alpha-adrenergic receptors (D1 and D2) in brain.
Common side effects
- Insomnia
- Restlessness
- Anxiety
- Depression
Contraindications
- Documented hypersensitivity to phenothiazines Coma, severe CNS depression, concurrent use of large amounts of CNS depressants, poorly controlled seizure disorder, subcortical brain damage Postoperative management of nausea/vomiting following pediatric surgery Children <2 years or weighing…
Known interactions (4)
- amisulpride + prochlorperazine Major
- cabergoline + prochlorperazine Major
- dopamine + prochlorperazine Moderate
- indapamide + prochlorperazine Moderate
Related conditions
Frequently asked questions
What drug class is prochlorperazine?
prochlorperazine belongs to: Central Nervous System.
How does prochlorperazine work?
Antiemetic: Antidopaminergic effect, blocking dopamine receptors in the brain, blocking vagus nerve in GI tract. Antipsychotic: Blocking mesolimbic dopamine receptors, and blocking alpha-adrenergic receptors (D1 and D2) in brain.
What are the common side effects of prochlorperazine?
Insomnia, Restlessness, Anxiety, Depression
Which drugs interact with prochlorperazine?
amisulpride, cabergoline, dopamine, indapamide
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