Drug interactions
Alprazolam + Ribociclib
Severity: Moderate
Alprazolam and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate to strong CYP3A4 inhibitor and can increase alprazolam exposure, causing more sedation, confusion and psychomotor impairment. The effect is greater in older or frail patients.
What this interaction means in plain words
Alprazolam and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing alprazolam clearance.
What to do
Consider a reduced alprazolam dose and monitor for oversedation while on ribociclib. Reassess the dose after ribociclib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Ribociclib?
MediHelp rates the interaction as moderate. Alprazolam and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate to strong CYP3A4 inhibitor and can increase alprazolam exposure, causing more sedation, confusion and psychomotor impairment. The effect is greater in older or frail patients.
How serious is the interaction between Alprazolam and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a reduced alprazolam dose and monitor for oversedation while on ribociclib. Reassess the dose after ribociclib is discontinued.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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