Drug reference
ribociclib
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Oncology (Anti Neoplastics)
Mechanism of action
Inhibits cyclin dependent kinases (CDK) 4 and 6; blocks cellular proliferation of G1 into S phase of the cell cycle These kinases are activated upon binding to D cyclins and play a crucial role in signaling pathways which lead to cell cycle progression and cellular proliferation;
Common side effects
- Alopecia
- Neutropenia
- Leukopenia
- Fatigue
- Nausea
- Diarrhea
Known interactions (6)
- flibanserin + ribociclib Contraindicated
- alfuzosin + ribociclib Major
- colchicine + ribociclib Major
- fluconazole + ribociclib Major
- aprepitant + ribociclib Moderate
- budesonide + ribociclib Moderate
Related conditions
Frequently asked questions
What drug class is ribociclib?
ribociclib belongs to: Oncology.
How does ribociclib work?
Inhibits cyclin dependent kinases (CDK) 4 and 6; blocks cellular proliferation of G1 into S phase of the cell cycle These kinases are activated upon binding to D cyclins and play a crucial role in signaling pathways which lead to cell cycle progression and cellular proliferation;
What are the common side effects of ribociclib?
Alopecia, Neutropenia, Leukopenia, Fatigue, Nausea, Diarrhea
Which drugs interact with ribociclib?
flibanserin, alfuzosin, colchicine, fluconazole, aprepitant, budesonide
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