Drug interactions
Alprazolam + Zafirlukast
Severity: Minor
Alprazolam and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast inhibits CYP3A4 in vitro, and alprazolam is cleared mainly by this enzyme. Alprazolam exposure may increase slightly, with more sedation or psychomotor impairment, although a clinically important effect has not been well demonstrated.
What this interaction means in plain words
Alprazolam and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alprazolam belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast weakly inhibits CYP3A4, reducing alprazolam metabolism.
What to do
Monitor for excess sedation and reduce the alprazolam dose if drowsiness or impaired coordination occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Zafirlukast?
MediHelp rates the interaction as minor. Alprazolam and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast inhibits CYP3A4 in vitro, and alprazolam is cleared mainly by this enzyme. Alprazolam exposure may increase slightly, with more sedation or psychomotor impairment, although a clinically important effect has not been well demonstrated.
How serious is the interaction between Alprazolam and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce the alprazolam dose if drowsiness or impaired coordination occurs.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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