Drug interactions
Alprazolam + Ziprasidone
Severity: Moderate
Alprazolam and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs can add to drowsiness, dizziness and impaired alertness. Ziprasidone also prolongs the QT interval, but alprazolam does not meaningfully alter this effect.
What this interaction means in plain words
Alprazolam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and the sedative receptor effects of ziprasidone.
What to do
Monitor sedation and counsel about driving and alcohol. Use the lowest effective doses and follow routine QT precautions for ziprasidone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Ziprasidone?
MediHelp rates the interaction as moderate. Alprazolam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The two drugs can add to drowsiness, dizziness and impaired alertness. Ziprasidone also prolongs the QT interval, but alprazolam does not meaningfully alter this effect.
How serious is the interaction between Alprazolam and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and counsel about driving and alcohol. Use the lowest effective doses and follow routine QT precautions for ziprasidone.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
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