Drug interactions
Alteplase + Antithrombin alfa
Severity: Moderate
Alteplase and Antithrombin alfa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin alfa potentiates heparin-type anticoagulation and, with a thrombolytic such as alteplase, may add to bleeding risk. Bleeding at puncture sites or internally is the main concern.
What this interaction means in plain words
Alteplase and Antithrombin alfa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticoagulant and fibrinolytic effects increase the tendency to hemorrhage.
What to do
Monitor for bleeding and coagulation parameters such as aPTT and fibrinogen during concurrent use. Limit invasive procedures and punctures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Antithrombin alfa?
MediHelp rates the interaction as moderate. Alteplase and Antithrombin alfa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin alfa potentiates heparin-type anticoagulation and, with a thrombolytic such as alteplase, may add to bleeding risk. Bleeding at puncture sites or internally is the main concern.
How serious is the interaction between Alteplase and Antithrombin alfa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters such as aPTT and fibrinogen during concurrent use. Limit invasive procedures and punctures.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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