Drug interactions
Alteplase + Antithrombin iii
Severity: Moderate
Alteplase and Antithrombin iii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances the effect of heparin and may increase hemorrhage risk when given with alteplase. Bleeding from catheter sites or internally is the key concern.
What this interaction means in plain words
Alteplase and Antithrombin iii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticoagulant and fibrinolytic effects increase the tendency to hemorrhage.
What to do
Monitor for bleeding and coagulation parameters including aPTT and fibrinogen. Avoid unnecessary invasive procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Antithrombin iii?
MediHelp rates the interaction as moderate. Alteplase and Antithrombin iii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances the effect of heparin and may increase hemorrhage risk when given with alteplase. Bleeding from catheter sites or internally is the key concern.
How serious is the interaction between Alteplase and Antithrombin iii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters including aPTT and fibrinogen. Avoid unnecessary invasive procedures.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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