Drug interactions
Alteplase + Azficel-t
Severity: Moderate
Alteplase and Azficel-t: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azficel-T is an autologous cell therapy injected intradermally after a skin biopsy. Thrombolytics impair clot formation and may increase bruising and bleeding at the biopsy and injection sites.
What this interaction means in plain words
Alteplase and Azficel-t can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fibrinolysis by alteplase may promote local bleeding and bruising at procedural sites.
What to do
Alteplase is used in emergencies, so weigh the need for it against deferring azficel-T biopsy or injections. Monitor biopsy and injection sites for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Azficel-t?
MediHelp rates the interaction as moderate. Alteplase and Azficel-t can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azficel-T is an autologous cell therapy injected intradermally after a skin biopsy. Thrombolytics impair clot formation and may increase bruising and bleeding at the biopsy and injection sites.
How serious is the interaction between Alteplase and Azficel-t?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Alteplase is used in emergencies, so weigh the need for it against deferring azficel-T biopsy or injections. Monitor biopsy and injection sites for bleeding.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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