Drug interactions
Alteplase + Choline magnesium trisalicylate
Severity: Moderate
Alteplase and Choline magnesium trisalicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can modestly impair platelet function and may add to bleeding when combined with alteplase. Choline magnesium trisalicylate has relatively weak platelet effects compared with aspirin.
What this interaction means in plain words
Alteplase and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate-related platelet inhibition adds to fibrinolytic bleeding risk.
What to do
Monitor for bleeding and consider withholding the salicylate around thrombolysis unless indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Choline magnesium trisalicylate?
MediHelp rates the interaction as moderate. Alteplase and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates can modestly impair platelet function and may add to bleeding when combined with alteplase. Choline magnesium trisalicylate has relatively weak platelet effects compared with aspirin.
How serious is the interaction between Alteplase and Choline magnesium trisalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider withholding the salicylate around thrombolysis unless indicated.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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