Drug interactions
Alteplase + Devil's claw
Severity: Moderate
Alteplase and Devil's claw: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Devil's claw has been linked to antiplatelet or anticoagulant-like effects and isolated reports of increased bleeding. Combined with a thrombolytic, it could add to bleeding risk, though the evidence is limited.
What this interaction means in plain words
Alteplase and Devil's claw can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible weak antiplatelet or anticoagulant activity of the herb adding to fibrinolysis; the mechanism is not well established.
What to do
Ask patients about herbal use and advise stopping devil's claw before elective thrombolytic or anticoagulant therapy. Monitor for bleeding if exposure occurred.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Devil's claw?
MediHelp rates the interaction as moderate. Alteplase and Devil's claw can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Devil's claw has been linked to antiplatelet or anticoagulant-like effects and isolated reports of increased bleeding. Combined with a thrombolytic, it could add to bleeding risk, though the evidence is limited.
How serious is the interaction between Alteplase and Devil's claw?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and advise stopping devil's claw before elective thrombolytic or anticoagulant therapy. Monitor for bleeding if exposure occurred.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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