Drug interactions
Alteplase + Dong quai
Severity: Moderate
Alteplase and Dong quai: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dong quai contains coumarin-like constituents and may increase bleeding tendency, which could add to the effect of alteplase. Evidence is mainly from case reports with warfarin.
What this interaction means in plain words
Alteplase and Dong quai can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Coumarin-like compounds and possible platelet inhibition may add to fibrinolytic bleeding risk.
What to do
Ask about herbal use and discontinue dong quai where feasible. Monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Dong quai?
MediHelp rates the interaction as moderate. Alteplase and Dong quai can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dong quai contains coumarin-like constituents and may increase bleeding tendency, which could add to the effect of alteplase. Evidence is mainly from case reports with warfarin.
How serious is the interaction between Alteplase and Dong quai?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about herbal use and discontinue dong quai where feasible. Monitor for bleeding.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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