Drug interactions
Alteplase + Fish oil triglycerides
Severity: Minor
Alteplase and Fish oil triglycerides: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omega-3 fatty acids at therapeutic doses modestly impair platelet aggregation and may prolong bleeding time. With a thrombolytic, this may add slightly to the bleeding risk.
What this interaction means in plain words
Alteplase and Fish oil triglycerides have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Omega-3 fatty acids reduce platelet aggregation, adding to the hemostatic impairment from fibrinolysis.
What to do
No routine change is needed, but watch for bleeding after alteplase in patients on high-dose fish oil. Review the need for other bleeding-risk drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Fish oil triglycerides?
MediHelp rates the interaction as minor. Alteplase and Fish oil triglycerides have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omega-3 fatty acids at therapeutic doses modestly impair platelet aggregation and may prolong bleeding time. With a thrombolytic, this may add slightly to the bleeding risk.
How serious is the interaction between Alteplase and Fish oil triglycerides?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed, but watch for bleeding after alteplase in patients on high-dose fish oil. Review the need for other bleeding-risk drugs.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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