Drug interactions
Alteplase + Forskolin
Severity: Minor
Alteplase and Forskolin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Forskolin inhibits platelet aggregation by raising cAMP and could add to bleeding risk with alteplase. Clinical data are sparse.
What this interaction means in plain words
Alteplase and Forskolin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Adenylate cyclase activation raises platelet cAMP, inhibiting aggregation additively with fibrinolysis.
What to do
Ask about supplement use and avoid forskolin around thrombolysis. Monitor for bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Forskolin?
MediHelp rates the interaction as minor. Alteplase and Forskolin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Forskolin inhibits platelet aggregation by raising cAMP and could add to bleeding risk with alteplase. Clinical data are sparse.
How serious is the interaction between Alteplase and Forskolin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about supplement use and avoid forskolin around thrombolysis. Monitor for bleeding.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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