Drug interactions
Alteplase + Horse chestnut seed
Severity: Minor
Alteplase and Horse chestnut seed: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Horse chestnut contains aesculin, a coumarin derivative with possible antithrombotic activity, and may theoretically add to bleeding with alteplase. Clinical evidence is scant.
What this interaction means in plain words
Alteplase and Horse chestnut seed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Coumarin-like constituents may add anticoagulant effect, though this is not well established.
What to do
Ask about herbal use and stop horse chestnut before elective procedures. Monitor for bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Horse chestnut seed?
MediHelp rates the interaction as minor. Alteplase and Horse chestnut seed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Horse chestnut contains aesculin, a coumarin derivative with possible antithrombotic activity, and may theoretically add to bleeding with alteplase. Clinical evidence is scant.
How serious is the interaction between Alteplase and Horse chestnut seed?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about herbal use and stop horse chestnut before elective procedures. Monitor for bleeding.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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