Drug interactions
Alteplase + Reishi
Severity: Minor
Alteplase and Reishi: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reishi mushroom has shown antiplatelet activity in laboratory studies and might add to bleeding with alteplase. Clinical evidence is lacking.
What this interaction means in plain words
Alteplase and Reishi have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reishi constituents may inhibit platelet aggregation, which could add to fibrinolytic bleeding risk.
What to do
Ask about supplement use and withhold reishi before elective thrombolysis. Monitor for bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Reishi?
MediHelp rates the interaction as minor. Alteplase and Reishi have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reishi mushroom has shown antiplatelet activity in laboratory studies and might add to bleeding with alteplase. Clinical evidence is lacking.
How serious is the interaction between Alteplase and Reishi?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about supplement use and withhold reishi before elective thrombolysis. Monitor for bleeding.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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