Drug interactions
Alteplase + Salicylates
Severity: Moderate
Alteplase and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-aspirin salicylates generally have weaker antiplatelet effects, but they may still influence hemostasis and irritate the gastric mucosa. Combined with alteplase, they may add modestly to the bleeding risk.
What this interaction means in plain words
Alteplase and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates may weakly inhibit platelet function and injure the GI mucosa, adding to fibrinolysis-related bleeding.
What to do
Avoid unnecessary salicylate use around thrombolysis. Monitor for bleeding, especially GI.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Salicylates?
MediHelp rates the interaction as moderate. Alteplase and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-aspirin salicylates generally have weaker antiplatelet effects, but they may still influence hemostasis and irritate the gastric mucosa. Combined with alteplase, they may add modestly to the bleeding risk.
How serious is the interaction between Alteplase and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary salicylate use around thrombolysis. Monitor for bleeding, especially GI.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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