Drug interactions
Alteplase + Salsalate
Severity: Minor
Alteplase and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate with little platelet inhibition, but it can still cause GI irritation. Combined with alteplase, the added bleeding risk is likely small.
What this interaction means in plain words
Alteplase and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak, mostly reversible effect on platelet prostaglandin synthesis and GI mucosal irritation adding to fibrinolysis.
What to do
Hold salsalate when thrombolysis is planned if feasible, and monitor for bleeding. No further action is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Salsalate?
MediHelp rates the interaction as minor. Alteplase and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is a non-acetylated salicylate with little platelet inhibition, but it can still cause GI irritation. Combined with alteplase, the added bleeding risk is likely small.
How serious is the interaction between Alteplase and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold salsalate when thrombolysis is planned if feasible, and monitor for bleeding. No further action is usually required.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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