Drug interactions
Alteplase + Vortioxetine
Severity: Moderate
Alteplase and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine, like other serotonergic antidepressants, can impair platelet serotonin uptake and slightly raise bleeding risk. When combined with alteplase the additive effect may modestly increase bleeding.
What this interaction means in plain words
Alteplase and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alteplase belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake by vortioxetine impairs aggregation, adding to alteplase fibrinolytic effect.
What to do
Monitor for bleeding signs after thrombolysis; continuing the antidepressant is generally acceptable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Vortioxetine?
MediHelp rates the interaction as moderate. Alteplase and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine, like other serotonergic antidepressants, can impair platelet serotonin uptake and slightly raise bleeding risk. When combined with alteplase the additive effect may modestly increase bleeding.
How serious is the interaction between Alteplase and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs after thrombolysis; continuing the antidepressant is generally acceptable.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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