Drug interactions
Aluminum hydroxide + Capecitabine
Severity: Minor
Aluminum hydroxide and Capecitabine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminum hydroxide and magnesium hydroxide antacids slightly raised the exposure to capecitabine and its metabolite in a small study, but the change was not considered clinically significant. Dose adjustment has not been needed.
What this interaction means in plain words
Aluminum hydroxide and Capecitabine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aluminum hydroxide belongs to Gastrointestinal Tract; Capecitabine belongs to Oncology.
Why it happens
Mechanism unclear; antacid may modestly change capecitabine absorption.
What to do
No dose adjustment is required. Be aware of the interaction if toxicity increases after starting antacids.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aluminum hydroxide
Other interactions of Capecitabine
Frequently asked questions
Can I take Aluminum hydroxide with Capecitabine?
MediHelp rates the interaction as minor. Aluminum hydroxide and Capecitabine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aluminum hydroxide and magnesium hydroxide antacids slightly raised the exposure to capecitabine and its metabolite in a small study, but the change was not considered clinically significant. Dose adjustment has not been needed.
How serious is the interaction between Aluminum hydroxide and Capecitabine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Be aware of the interaction if toxicity increases after starting antacids.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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