Drug interactions
Aluminum hydroxide + Enalapril-hydrochlorothiazide
Severity: Minor
Aluminum hydroxide and Enalapril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing aluminum may reduce the absorption of ACE inhibitors, which may slightly reduce antihypertensive effect. The clinical impact is usually modest.
What this interaction means in plain words
Aluminum hydroxide and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aluminum hydroxide belongs to Gastrointestinal Tract; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Possible reduction in gastrointestinal absorption of the ACE inhibitor, mechanism not firmly established.
What to do
Separate antacid and enalapril dosing by about 2 hours. Monitor blood pressure if antacids are used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Aluminum hydroxide and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids containing aluminum may reduce the absorption of ACE inhibitors, which may slightly reduce antihypertensive effect. The clinical impact is usually modest.
How serious is the interaction between Aluminum hydroxide and Enalapril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate antacid and enalapril dosing by about 2 hours. Monitor blood pressure if antacids are used regularly.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Amifostine, Amiloride. The full list is on the Enalapril-hydrochlorothiazide page.
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