Drug interactions
Aluminum hydroxide + Fosinopril-hydrochlorothiazide
Severity: Minor
Aluminum hydroxide and Fosinopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing aluminum may reduce the oral absorption of ACE inhibitors such as fosinopril, which can modestly lessen its blood pressure lowering effect. The change is generally small and variable.
What this interaction means in plain words
Aluminum hydroxide and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aluminum hydroxide belongs to Gastrointestinal Tract; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Reduced gastrointestinal absorption of fosinopril, likely through adsorption or binding to the antacid.
What to do
Separate administration by at least 2 hours, taking fosinopril first. Check blood pressure if antacids are used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Aluminum hydroxide and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids containing aluminum may reduce the oral absorption of ACE inhibitors such as fosinopril, which can modestly lessen its blood pressure lowering effect. The change is generally small and variable.
How serious is the interaction between Aluminum hydroxide and Fosinopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 2 hours, taking fosinopril first. Check blood pressure if antacids are used regularly.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Aldesleukin, Amifostine. The full list is on the Fosinopril-hydrochlorothiazide page.
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