Drug interactions
Aluminum hydroxide + Ketoconazole
Severity: Moderate
Aluminum hydroxide and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole needs an acidic stomach to dissolve, so raising gastric pH with an antacid can lower its absorption. Reduced exposure may cause antifungal failure.
What this interaction means in plain words
Aluminum hydroxide and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Ketoconazole belongs to Anti Fungals.
Why it happens
Increased gastric pH reduces dissolution and absorption of ketoconazole, a weak base with pH-dependent solubility.
What to do
Give the antacid at least 2 hours after ketoconazole. Monitor clinical response to antifungal therapy if antacids are used regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
Frequently asked questions
Can I take Aluminum hydroxide with Ketoconazole?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole needs an acidic stomach to dissolve, so raising gastric pH with an antacid can lower its absorption. Reduced exposure may cause antifungal failure.
How serious is the interaction between Aluminum hydroxide and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the antacid at least 2 hours after ketoconazole. Monitor clinical response to antifungal therapy if antacids are used regularly.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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