Drug interactions
Aluminum hydroxide + Nilotinib
Severity: Moderate
Aluminum hydroxide and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib absorption depends on an acidic gastric environment, and antacids may lower its exposure. This may reduce efficacy.
What this interaction means in plain words
Aluminum hydroxide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Nilotinib belongs to Oncology.
Why it happens
Antacid-induced rise in gastric pH reduces nilotinib solubility and absorption.
What to do
Give the antacid at least 2 hours before or 2 hours after nilotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Nilotinib?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib absorption depends on an acidic gastric environment, and antacids may lower its exposure. This may reduce efficacy.
How serious is the interaction between Aluminum hydroxide and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the antacid at least 2 hours before or 2 hours after nilotinib.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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