Drug interactions
Aluminum hydroxide + Posaconazole
Severity: Minor
Aluminum hydroxide and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole oral suspension absorption depends on gastric acidity, and acid suppression lowers its exposure. Antacids have been reported to have little effect on the suspension, and delayed-release tablets are not meaningfully affected. Clinical significance is therefore low.
What this interaction means in plain words
Aluminum hydroxide and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aluminum hydroxide belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Higher gastric pH could reduce dissolution and absorption of posaconazole, mainly the oral suspension.
What to do
No routine dose change is needed. Prefer delayed-release tablets or take the suspension with food, and consider checking posaconazole levels if there is concern about exposure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Posaconazole?
MediHelp rates the interaction as minor. Aluminum hydroxide and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole oral suspension absorption depends on gastric acidity, and acid suppression lowers its exposure. Antacids have been reported to have little effect on the suspension, and delayed-release tablets are not meaningfully affected. Clinical significance is therefore low.
How serious is the interaction between Aluminum hydroxide and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Prefer delayed-release tablets or take the suspension with food, and consider checking posaconazole levels if there is concern about exposure.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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